Abstract: To extract the main components from Carthamus tinctorius L.,the Box-Behnken design method andresponse surface methodology were used to optimize the extraction process of C. tinctorius L.;Hydroxy-saffloweryellow A and kaempferol-3-O-rutinoside were the main flavonoids in C. tinctorius L. petals. The results showedthat Ultrasonic extraction method were the optimal extraction technology:using 57% methanol as solvent,liquid-material ratio was 0.1∶25 g·m L-1,ultrasonic temperature was 70℃,extraction time was 45 min,ultrasound power was 177 W,Under these conditions,hydroxy-safflower yellow A extraction yield was 1.74%,kaempferol-3-O-rutinoside extraction yield was 1.53%. The safflower main ingredient extraction was recommendedto use ultrasonic extraction.