Abstract: Heavy metal pollution not only affected the effective area of the soil,restricted the distribution ofvegetation,but also harmed the food chain and human health,and cadmium（Cd）pollution was particularlyprominent.It was urgent to select plants with strong heavy metal tolerance for bioremediation in tailings areas.For Broussonetia papyrifera was a pioneer tree species in heavy metals polluted soil,In order to explore themolecular mechanism of B.papyrifera in response to heavy metal stress,a basic leucine zipper（b ZIP）transcription factor（named Bpb ZIP1）from B.papyrifera was cloned,and its basic biological information,Cdstress response and the function of transformed yeast were analyzed to predict the role of Bpb ZIP1 in response toCd.The results showed that the open reading frame of Bpb ZIP1 was 1 713 bp,the encoded protein contained570 amino acids,the molecular weight was 62 902.38 Da,and the theoretical isoelectric point was 4.62.It hada close evolutionary relationship with Arabidopsis thaliana Atb ZIP1.Under 150 μmol·L^-1 CdCl₂ treatment,theBpb ZIP1 in B.papyrifera could be induced differently,and the expression of Bpb ZIP1 in roots was 17.4-foldhigher than that in controls at 3 h after induction.Transformation of Bpb ZIP1 into yeast could significantly improve Cd resistance of transgenic yeasts.When the CdCl₂ concentration was higher than 0.6%,the growthvigor of transgenic yeast was 1.54-1.71-fold higher than that in controls.These results suggested that Bpb ZIP1 gene could positively respond to Cd stress,and its expression benefited Cd stress tolerance.Bpb ZIP1 was animportant candidate in response to Cd stress of B.papyrifera.